发现者/寻路者®；帕尼妥单抗生物测定试剂盒/1000dp（10x96孔）/93-1051Y3-00094
商品编号：
93-1051Y3-00094
市场价：
¥165180.00
美元价：
99108.00
产品分类：
细胞代谢
公司分类：
cellular_metabolism
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
The PathHunter® Dimerization Bioassay detects ligand induced dimerization of two subunits of a receptor-dimer pair.The cells have been engineered to co-express one receptor subunit fused to Enzyme Donor (ED), and a second dimer partner fused to Enzyme Acceptor (EA).Cytoplasmic tail may have been deleted from one or both receptors.Binding of an agonist to one receptor subunit induces it to interact with its dimer partner,forcing complementation of the two enzyme fragments.This results in the formation of a functional enzyme that hydrolyzes a substrate to generate a chemiluminescent signal.
- Target/Description
- Epidermal growth factor receptor
- Group
- Receptor Tyrosine Kinase
- Cell Background
- U2OS
- Species
- Human
- Accession Number
- NM_005228.3
- Agonist/Ligand
- Recombinant Human EGF
- Antagonist/Inhibitor
- Vectibix (Panitumumab)
- Assay Measures
- EGFR/ErbB2 Dimerization
- Bioassay Target Name
- EGFR/ErbB2
- Assay Qualified With
- Vectibix®
- Drug Trademark Owner
- Vectibix® is a registered trademark of Amgen Inc.
How it works
The above graph is an example of a typical dose-response curve for the Panitumumab Bioassay, generated using the protocol outlined in the user manual. Data was acquired using the EnVision Microplate Reader (PerkinElmer).
品牌介绍
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苏州蚂蚁淘实验试剂有限公司DiscoveRx专业代理，具体产品信息欢迎电询：
DiscoveRx 公司一家以提供包括 G 蛋白耦联受体，激酶，NHR 和蛋白酶创新型细胞实验方法的主要供应商。DiscoveRx’s PathHunter(TM) beta-Arrestin 和 HitHunter(TM) cAMP assays 是均相化学发光探测实验，该种实验平台已经迅速成为药物临床前研发中利用G蛋白耦联受体筛选分析药物的平台。
http://www.discoverx.com
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